Signal’s website was also inaccessible in China on Tuesday morning.
The app was still available on Apple’s China app store as of Tuesday morning, and the app and website appeared to be working normally in Hong Kong.
Signal’s press team did not immediately respond to a request for comment.
The Cyberspace Administration of China could not immediately be reached for comment.
The app was already unavailable on third-party Android stores in China, where Google services are largely blocked.
On several occasions the app had previously stopped working in China without VPN with no reason given, only for usage to resume.
Signal saw a surge in downloads worldwide after January 6 when WhatsApp updated its privacy terms, reserving the right to share user data, including location and phone number, with its parent Facebook Inc and units such as Instagram and Messenger.
Signal had been downloaded close to 510,000 times on iOS in China, and has been downloaded 100 million times worldwide on the App Store and Google Play combined, according to data company Sensor Tower.
(Reporting by David Kirton in Shenzhen; Additional reporting by the Beijing newsroom; Editing by Michael Perry)