Research Scientist, Target Validation – Functional Genomics
Competitive salary & benefits
Meaningful Impact. Make a more meaningful contribution. Impact patients' lives every day!
Are you an experienced, dedicated Research Scientist looking for a role where your expertise can make an extraordinary impact? Then we have an exciting opportunity to join our rapidly growing Functional Genomics (FGX) group who are responsible for the identification of novel targets to support AstraZeneca's clinical pipeline.
This is a position where you will actively contribute to the development and improvement of current functional genomics approaches to maintain scientific perfection within our Discovery Sciences team!
Diverse Minds. Bold Disruptors. Meaningful Impact.
AstraZeneca is a science-led, global biopharmaceutical company, committed to improving the health and lives of people across the globe through our research and development platform and a growing late-stage pipeline. With a presence in over 100 countries, we have strength in emerging markets, and our medicines are used by millions of patients and clinicians worldwide. Working here means being results-oriented and working together to make the impossible a reality!
What'll you do?
You'll be working in the Functional Genomics Target Validation team – a growing team of passionate scientists based in a dynamic environment, focused on the validation and mechanistic annotation of hit lists coming from functional genomics screens, to translate them into new drug targets for our oncology pipeline.
This is a laboratory-based role, where you will craft and resource experiments. You will be comfortable working as part of a cross functional team to deliver and interpret data, working together to determine next steps to drive projects forwards.
We are looking for applicants with strong cellular biology expertise and a passion for rigorous validation of novel target opportunities. A broad technical knowledge is required to assay the functions of large numbers of genes involved in different signalling pathways to deliver robust datasets that impact on target decisions.
- Ph.D in Molecular or Cell biology or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry
- Experience of cell culture including a practical understanding of assay optimisation to enable generation of robust cellular assays
- Proven experience in molecular and cell biology techniques, including transfection and transduction methods, generation of engineered cell lines, high content imaging, transcriptomics assays, assessment of cellular signalling
- Experience in the use of patient-derived models/organoids
- Excellent communication and networking skills with experience of interacting optimally across subject areas and expertise.
- Understanding of critical steps in target validation campaigns
- Capable of scouting for scientific and technical developments in the fields of CRISPR screening, genome engineering and target validation
- Background in Cancer Biology
An exciting bioscience hotspot, Cambridge is home to one of AstraZeneca's three strategic, global R&D Centres, alongside Gothenburg and Gaithersburg. Over 3,600 employees work from our various sites across Cambridge and our offices are internationally renowned for attracting high performers, including several Nobel prize winners.
Currently based at our Darwin building on the Cambridge Science Park, the Functional Genomics team are unbelievably excited for their pending relocation to our brand new, state-of-the-art R&D facility which was officially un-veiled this week by His Royal Highness, The Prince of Wales.
The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it will have more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.
Find out more about our Cambridge campus and the DISC, here: https://www.astrazeneca.com/our-company/our-locations/cambridge.html
Pioneer a new future to meet global healthcare challenges
At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. Our inclusive culture champions diversity and collaboration. We always committed to life-long learning, growth and personal development.
So, what's next?
Please complete your application before the below closing date.
This role is open from Thursday, 16th December 2021 and we welcome your application no later than Monday, 31st January 2022.
Where can I find out more?
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